ncRNA basic information
ncRNA ID:
ENSG00000234741
ncRNA Database:
Ensembl
ncRNA Name:
GAS5
ncRNA Type:
lncRNA
ncRNA Expression:
down-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
PTEN
ncRNA Pathway:
mTOR signaling pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00072 (BTD00098, BIOD00098)
Drug Name:
Trastuzumab
Drug Method:
The role of GAS5 in breast cancer cells was detected using microarray analysis, Immunohistochemistry and scoring system, MTT assay, colony formation assay, qRT-PCR assay, western blot assay and animal studies, etc.
Drug Response:
resistant
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line (SKBR-3,SKBR-3/Tr)
Other information
Title:
Downregulation of LncRNA GAS5 causes trastuzumab resistance in breast cancer.
Journal:
Oncotarget
Published:
2016
PubMed ID:
27034004