ncRNA basic information
ncRNA ID:
ENSG00000228630
ncRNA Database:
Ensembl
ncRNA Name:
HOTAIR
ncRNA Type:
lncRNA
ncRNA Expression:
down-regulated
ncRNA Method:
RT-qPCR
ncRNA Target Gene:
NA
ncRNA Pathway:
mTOR signaling pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00818 (APRD01201, EXPT02558, DB05893)
Drug Name:
Propofol
Drug Method:
In vitro, the different concentrations of propofol were co-incubated with cervical cancer cell lines, including Hela, Caski and C-33A cells respectively. The pcDNA-HOTAIR plasmid was transfected into cells after the treatment of 10 ug/ml propofol. The cell viability and apoptosis were detected by MTT assay and TUNEL method. In vivo, propofol was injected into mice of transplantation tumor with Caski cells or with pcDNA-HOTAIR treated Caski cells.
Drug Response:
sensitive
Cancer basic information
Cancer:
cervical cancer
Tissue/Cell:
cell line (HeLa, Caski and C33A )
Other information
Title:
Propofol promotes cell apoptosis via inhibiting HOTAIR mediated mTOR pathway in cervical cancer.
Journal:
Biochem Biophys Res Commun
Published:
2015
PubMed ID:
26523512