ncRNA basic information
ncRNA ID:
ENSG00000114841
ncRNA Database:
Ensembl
ncRNA Name:
DNAH1
ncRNA Type:
lncRNA
ncRNA Expression:
down-regulated
ncRNA Method:
PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
predicted
drug basic information
Drug ID:
DB00541 (APRD00495)
Drug Name:
Vincristine
Drug Method:
A cDNA library of HCT-8 VCR-resistant colon cancer cell was established through PCR amplification. Using HiSeq 2500 sequencing and bioinformatic methods, we identified lncRNAs showing different expression levels in drug-resistant and non-resistant cells, and constructed expression profiles of the lncRNA differences. The pretreatment of data was quality controlled using FastQC software. Transcription of lncRNA was calculated using Fragments Per Kilobase of transcript per Million fragments mapped (FPKM). To reveal the potential functions of these lncRNAs, we applied GO analysis to study the differentially expressed lncRNAs.
Drug Response:
resistant
Cancer basic information
Cancer:
colon cancer
Tissue/Cell:
cell line (HCT-8,HCT-8/VCR )
Other information
Title:
Expression profile analysis of long non-coding RNA associated with vincristine resistance in colon cancer cells by next-generation sequencing.
Journal:
Gene
Published:
2015
PubMed ID:
26164760