ncRNA basic information
ncRNA ID:
ENSG00000214548
ncRNA Database:
Ensembl
ncRNA Name:
MEG3
ncRNA Type:
lncRNA
ncRNA Expression:
down-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of lncRNA were determined by qRT-PCR and those of protein were by Western blot analysis. lncRNA microarray was used to test the lncrna expression in different cell lines . MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of lncRNAs. Flow Cytometric Assay was used to determine if cells were viable, apoptotic, or necrotic.
Drug Response:
resistant
Cancer basic information
Cancer:
lung adenocarcinoma
Tissue/Cell:
cell line (A549,A549/DDP)
Other information
Title:
The Long Noncoding RNA MEG3 Contributes to Cisplatin Resistance of Human Lung Adenocarcinoma.
Journal:
PLoS One
Published:
2015
PubMed ID:
25992654