ncRNA basic information
ncRNA ID:
ENSG00000249859
ncRNA Database:
Ensembl
ncRNA Name:
PVT1
ncRNA Type:
lncRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
In this study, the mRNA levels of PVT1 in gastric cancer tissues of cisplatin-resistant patients and two kinds of cisplatin-resistant cells BGC823/DDP and SGC7901/DDP were detected by qRT-PCR. The influence of PVT1 knockdown or overexpression on anticancer drug resistance was assessed by measuring the cytotoxicity of cisplatin and the rate of apoptosis detected by CCK-8 assay and flow cytometry, respectively. Further, we investigated the expression levels of MDR1, MRP, mTOR and HIF-1alpha by qRT-PCR and western blotting.
Drug Response:
resistant
Cancer basic information
Cancer:
stomach cancer
Tissue/Cell:
cell line (BGC823,SGC7901,BGC823/DDP and SGC7901/DDP)
Other information
Title:
Overexpression of long non-coding RNA PVT1 in gastric cancer cells promotes the development of multidrug resistance.
Journal:
Biochem Biophys Res Commun
Published:
2015
PubMed ID:
25956062