ncRNA basic information
ncRNA ID:
MI0000089
ncRNA Database:
miRBase
ncRNA Name:
miR-31
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
E2F6
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by Real-time PCR and those of protein were by Western blot analysis. The Cell Death Detection Elisa kit (Roche) was used to detect apoptosis following the manufacturers protocol.
Drug Response:
resistant
Cancer basic information
Cancer:
prostate cancer
Tissue/Cell:
cell line (RWPE-1, WPE1-NA22, WPE1-NB14, WPE1-NB11, WPE1-NB26, PC-3, LNCaP, 22Rv1, VCaP, and Du145)
Other information
Title:
Downregulation of miR-205 and miR-31 confers resistance to chemotherapy-induced apoptosis in prostate cancer cells.
Journal:
Cell Death Dis
Published:
2010
PubMed ID:
21368878