ncRNA basic information
ncRNA ID:
ENSG00000228630
ncRNA Database:
Ensembl
ncRNA Name:
HOTAIR
ncRNA Type:
lncRNA
ncRNA Expression:
down-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB01645 (EXPT01582)
Drug Name:
Genistein
Drug Method:
Microarray expression profiling of mRNAs, lncRNA and miRNA was undertaken in A549 cells and cisplatin resistant A549/CDDP cells. Differentially expressed mRNAs, lncRNAs and miRNAs, verified by realtime RT-PCR, were subjected to pathway analysis. Expression of NKD2 and Beta-catenin was assessed by realtime RT-PCR and western blot analysis. The effect of lncRNA AK126698 on cisplatin induced apoptosis was investigated by annexin-V/PI flow cytometry.
Drug Response:
sensitive
Cancer basic information
Cancer:
prostate cancer
Tissue/Cell:
cell line ( LNCaP, PC3, DU145,RWPE-1)
Other information
Title:
Genistein inhibits prostate cancer cell growth by targeting miR-34a and oncogenic HOTAIR.
Journal:
PLoS One
Published:
2013
PubMed ID:
23936419