ncRNA basic information
ncRNA ID:
MI0003646
ncRNA Database:
miRBase
ncRNA Name:
miR-33b
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
EIF5A-2
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00694 (APRD00521)
Drug Name:
Daunorubicin
Drug Method:
In this study, we aimed to study the effect of miR-33b in regulating sensitivity to daunorubicin (DNR) in acute myelocytic leukemia (AML). We used quantitative real-time polymerase chain reaction and Cell Counting Kit-8 assay to detect the level of miR-33b and cell viability. Cell apoptosis and the expression of eIF5A-2 and MCL-1 protein were detected by flow cytometry analysis and Western Blot analysis, respectively
Drug Response:
sensitive
Cancer basic information
Cancer:
acute myeloid leukemia
Tissue/Cell:
cell line
Other information
Title:
MicroRNA-33b regulates sensitivity to daunorubicin in acute myelocytic leukemia by regulating eukaryotic translation initiation factor 5A-2.
Journal:
J Cell Biochem
Published:
2019
PubMed ID:
31222822