ncRNA basic information
ncRNA ID:
MIMAT0003393
ncRNA Database:
miRBase
ncRNA Name:
miR-425-5p
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
PTCH1
ncRNA Pathway:
Hedgehog pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
In this study, LINC-PINT expression in normal and tumor tissues were studied. Using a bioinformatic approach, microRNA (miRNA) targets of LINC-PINT and gene targets of the miRNA were determined. The impact of LINC-PINT on cell proliferation and chemoresistance was determined. Further through a set of silencing and re-expression studies phenotype rescue was studied.
Drug Response:
sensitive
Cancer basic information
Cancer:
laryngeal carcinoma
Tissue/Cell:
cell line (Hep-2)
Other information
Title:
Long noncoding RNA LINC-PINT regulates laryngeal carcinoma cell stemness and chemoresistance through miR-425-5p/PTCH1/SHH axis.
Journal:
J Cell Physiol
Published:
2019
PubMed ID:
31131448