ncRNA basic information
ncRNA ID:
MI0000737
ncRNA Database:
miRBase
ncRNA Name:
miR-200a
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
predicted
drug basic information
Drug ID:
DB12385
Drug Name:
10-hydroxycamptothecin
Drug Method:
A sulforhodamine B (SRB) assay was used to analyze the sensitivity to HCPT of six gastric cancer cell lines. The miRNA and mRNA expression signatures in HCPT-resistant cell lines were then identified using DNA microarrays. Gene ontology and pathway analysis was conducted using GenMAPP2. A combined analysis was used to explore the relationship between the miRNAs and mRNAs.
Drug Response:
resistant
Cancer basic information
Cancer:
stomach cancer
Tissue/Cell:
cell lines (BGC-823, SGC-7901, MGC-803, HGC-27, NCI-N87, and AGS).
Other information
Title:
Genome-wide analysis of microRNA and mRNA expression signatures in hydroxycamptothecin-resistant gastric cancer cells.
Journal:
Acta Pharmacol Sin
Published:
2011
PubMed ID:
21293479