ncRNA basic information
ncRNA ID:
MI0003814
ncRNA Database:
miRBase
ncRNA Name:
miR-1271
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
RT-qPCR
ncRNA Target Gene:
mTOR
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
To investigate the drug resistance mechanism of mir-1271 in colorectal cancer.The expression levels of miRNA were determined by Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs.
Drug Response:
resistant
Cancer basic information
Cancer:
colorectal cancer
Tissue/Cell:
cell line (SW480 )
Other information
Title:
miR-1271 enhances the sensitivity of colorectal cancer cells to cisplatin.
Journal:
Exp Ther Med
Published:
2019
PubMed ID:
31086572