ncRNA basic information
ncRNA ID:
MIMAT0004752
ncRNA Database:
miRBase
ncRNA Name:
miR-20b-3p
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
MET
ncRNA Pathway:
c-MET Signaling Pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00853 (APRD00557)
Drug Name:
Temozolomide
Drug Method:
The role of Lnc-TALC in glioblastoma cells was detected using microarray analysis,coding potential analysis, cell apoptosis analysis, CCK-8 assay, colony formation assay, 5-Ethynyl-2'-deoxyuridine (EdU)assay, western blot, PCR, luciferase reporter assay and Xenograft model in vivo, etc.
Drug Response:
resistant
Cancer basic information
Cancer:
glioblastoma
Tissue/Cell:
cell line (LN229, U251, 551W, HG7,229R, 251R, 551WR, and HG7R)
Other information
Title:
Lnc-TALC promotes O6-methylguanine-DNA methyltransferase expression via regulating the c-Met pathway by competitively binding with miR-20b-3p.
Journal:
Nat Commun
Published:
2019
PubMed ID:
31053733