ncRNA basic information
ncRNA ID:
MI0000085
ncRNA Database:
miRBase
ncRNA Name:
miR-27a
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
CUL5
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The study was undertaken to unveil the therapeutic implications of miR-27a in ovarian cancer.The expression levels of miRNA were determined by Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs.
Drug Response:
resistant
Cancer basic information
Cancer:
ovarian cancer
Tissue/Cell:
tissue and cell line (Caov-4, SK-OV-3, OVACAR-3,UWB1.289,SV40, DoTc24510, GH329 and UACC-3247 )
Other information
Title:
MicroRNA-27a regulates the proliferation, chemosensitivity and invasion of human ovarian cancer cell lines by targeting Cullin 5.
Journal:
Arch Biochem Biophys
Published:
2019
PubMed ID:
31047870