ncRNA basic information
ncRNA ID:
MI0000284
ncRNA Database:
miRBase
ncRNA Name:
miR-204
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-qPCR
ncRNA Target Gene:
BIRC6
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB01169 (APRD00171)
Drug Name:
Arsenic trioxide
Drug Method:
In this study, the mechanism of mir-204 in acute myeloid leukemia and arsenic trioxide was studied.The expression levels of miRNA were determined by Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs.
Drug Response:
sensitive
Cancer basic information
Cancer:
acute myeloid leukemia
Tissue/Cell:
cell line
Other information
Title:
MicroRNA-204 potentiates the sensitivity of acute myeloid leukemia cells to arsenic trioxide.
Journal:
Oncol Res
Published:
2019
PubMed ID:
30982490