ncRNA basic information
ncRNA ID:
MI0001721
ncRNA Database:
miRBase
ncRNA Name:
miR-431
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
ZEB2
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00997 (APRD00185, DB05331, DB05847)
Drug Name:
Doxorubicin
Drug Method:
Samples from primary ACC tumors of 10 Stage IV patients were examined for differentially expressed miRNAs between a sensitive and resistant cohort. Candidate microRNAs were restored via transfection in two functional ACC cell lines. Gain of function and effects on apoptosis and cell cycle were assessed.
Drug Response:
sensitive
Cancer basic information
Cancer:
adrenocortical carcinoma
Tissue/Cell:
cell line
Other information
Title:
microRNA-431 as a Chemosensitizer and Potentiator of Drug Activity in Adrenocortical Carcinoma.
Journal:
Oncologist
Published:
2019
PubMed ID:
30918109