ncRNA basic information
ncRNA ID:
MIMAT0004658
ncRNA Database:
miRBase
ncRNA Name:
miR-155-3p
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
MYD88
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB01229 (APRD00259, DB05261, DB05927, DB05526, DB05281)
Drug Name:
Paclitaxel
Drug Method:
To investigate the relationship and mechanism between mir-155-3p and taxol resistance in human breast cancer.The expression levels of miRNA were determined by Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. Then test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs . Finally, the relevant targets were discussed.
Drug Response:
resistant
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line (MCF-7, SKBR-3, and MDA-MB-231 )
Other information
Title:
MiR-155-3p acts as a tumor suppressor and reverses paclitaxel resistance via negative regulation of MYD88 in human breast cancer.
Journal:
Gene
Published:
2019
PubMed ID:
30878390