ncRNA basic information
ncRNA ID:
MIMAT0000227
ncRNA Database:
miRBase
ncRNA Name:
miR-197-3p
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
p120-ctn
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by quantitative real time-polymerase chain reaction (qRT-PCR) and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs. The CCK-8 assay was used to monitor the growth of the cells .Mice models was used to test the role of miR-197-3p/p120 Catenin Axis .
Drug Response:
resistant
Cancer basic information
Cancer:
lung non-small cell carcinoma
Tissue/Cell:
cell lines (i.e.A549,H1299,H460,SPC-A-1,i.e. HBE,i.e. SPC-A-1)
Other information
Title:
LncRNA MALAT1 Depressed Chemo-Sensitivity of NSCLC Cells through Directly Functioning on miR-197-3p/p120 Catenin Axis.
Journal:
Mol Cells
Published:
2019
PubMed ID:
30841025