ncRNA basic information
ncRNA ID:
MIMAT0002176
ncRNA Database:
miRBase
ncRNA Name:
miR-485-3p
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
NF-YB
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00773 (APRD00239)
Drug Name:
Etoposide
Drug Method:
The expression levels of miRNA were determined by Reverse Transcriptase-PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs.
Drug Response:
sensitive
Cancer basic information
Cancer:
lymphocytic leukemia
Tissue/Cell:
cell line (CEM,CEM/VM-1-5,Rh30,Rh30/v1,HEK293T)
Other information
Title:
Novel regulation of nuclear factor-YB by miR-485-3p affects the expression of DNA topoisomerase IIalpha and drug responsiveness.
Journal:
Mol Pharmacol
Published:
2011
PubMed ID:
21252292