ncRNA basic information
ncRNA ID:
MIMAT0004676
ncRNA Database:
miRBase
ncRNA Name:
miR-34b-3p
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
CCND2 and P2RY1
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00997 (APRD00185, DB05331, DB05847)
Drug Name:
Adriamycin
Drug Method:
This research compared the multidrug-sensitive (5637) BCa cell line and the multidrug-resistant (EJ) BCa cell line. We found that CCND2 (G1/S-specific cyclin-D2) and P2RY1 (purinergic receptor P2Y1) were the targets of miR-34b-3p, as further validated by qRT-PCR (quantitative real-time polymerase chain reaction) and western blot analysis.
Drug Response:
sensitive
Cancer basic information
Cancer:
Bladder Cancer
Tissue/Cell:
cell line ( 5637,EJ)
Other information
Title:
MiR-34b-3p Represses the Multidrug-Chemoresistance of Bladder Cancer Cells by Regulating the CCND2 and P2RY1 Genes.
Journal:
Med Sci Monit
Published:
2019
PubMed ID:
30778022