ncRNA basic information
ncRNA ID:
MI0000466/MI0000467/MI0000468
ncRNA Database:
miRBase
ncRNA Name:
miR-9
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
EIF5A2
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00694 (APRD00521)
Drug Name:
Daunorubicin
Drug Method:
We explored the potential role of miR-9 in Dnr resistance in AML cells and its mechanism of action.The expression levels of miRNA were determined by Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and those of protein were by Western blot analysis.
Drug Response:
sensitive
Cancer basic information
Cancer:
acute myeloid leukemia
Tissue/Cell:
cell line (HL-60, KG-1, THP-1 and Kasumi-1 )
Other information
Title:
miR-9 Enhances the Chemosensitivity of AML Cells to Daunorubicin by Targeting the EIF5A2/MCL-1 Axis.
Journal:
Int J Biol Sci
Published:
2019
PubMed ID:
30745844