ncRNA basic information
ncRNA ID:
MI0000087
ncRNA Database:
miRBase
ncRNA Name:
miR-29a
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-qPCR
ncRNA Target Gene:
REV3L
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs.Cell viability was determined by Cell Counting Kit-8.
Drug Response:
sensitive
Cancer basic information
Cancer:
lung non-small cell carcinoma
Tissue/Cell:
cell lines (A549 and H1650, and 293 )
Other information
Title:
MicroRNA-29a enhances cisplatin sensitivity in non-small cell lung cancer through the regulation of REV3L.
Journal:
Mol Med Rep
Published:
2019
PubMed ID:
30535450