ncRNA basic information
ncRNA ID:
MI0000776
ncRNA Database:
miRBase
ncRNA Name:
miR-376c
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
ALK7
ncRNA Pathway:
Nodal-ALK7 pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by Rreal-time PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs.Cell proliferation and viability were determined using BrdU and WST-1 assays.TUNEL staining was used to detect apoptotic cell death.
Drug Response:
resistant
Cancer basic information
Cancer:
ovarian cancer
Tissue/Cell:
cell line (OV2008, A2780s)
Other information
Title:
MicroRNA 376c enhances ovarian cancer cell survival by targeting activin receptor-like kinase 7: implications for chemoresistance.
Journal:
J Cell Sci
Published:
2011
PubMed ID:
21224400