ncRNA basic information
ncRNA ID:
MIMAT0000436
ncRNA Database:
miRBase
ncRNA Name:
miR-144-3p
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
Nrf2
ncRNA Pathway:
Nrf2 signaling pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
In this study, the response of mir-144-3p to cisplatin in lung cancer was studied.The expression levels of miRNA were determined by Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs.
Drug Response:
resistant
Cancer basic information
Cancer:
lung cancer
Tissue/Cell:
cell line ( A549, H1299, HepG2, MCF-7, HeLa and Cos-7 )
Other information
Title:
miR-144-3p regulates the resistance of lung cancer to cisplatin by targeting Nrf2.
Journal:
Oncol Rep
Published:
2018
PubMed ID:
30542710