ncRNA basic information
ncRNA ID:
MIMAT0000243
ncRNA Database:
miRBase
ncRNA Name:
miR-148a-3p
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated/down-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
Bcl-2,Bim
ncRNA Pathway:
p53-dependent apoptosis-pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The current study investigated the role of different expression levels of miR-130a-3p and miR-148a-3p on drug resistance and tumor biology in four esophageal squamous cell carcinoma cell lines.The expression levels of miRNA were determined by Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. Apoptosis assays through flow cytometry.
Drug Response:
sensitive
Cancer basic information
Cancer:
esophageal squamous cell carcinoma
Tissue/Cell:
cell line (KYSE-70, KYSE-140, KYSE-270 and KYSE-410)
Other information
Title:
Complex role of miR-130a-3p and miR-148a-3p balance on drug resistance and tumor biology in esophageal squamous cell carcinoma
Journal:
Sci Rep
Published:
2018
PubMed ID:
30510209