ncRNA basic information
ncRNA ID:
MI0000272
ncRNA Database:
miRBase
ncRNA Name:
miR-182
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qPCR
ncRNA Target Gene:
BRCA1
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB09074 (DB05940)
Drug Name:
Olaparib
Drug Method:
The expression levels of miRNA were determined by quantitative PCR . Luciferase activity assay was used to verify the target genes of miRNAs. The xenograft mouse models was used to identify the relationshipe between miR-182 and PARP inhibitor, etc.
Drug Response:
sensitive
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line (HL60, K562,MCF-7)
Other information
Title:
miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors.
Journal:
Mol Cell
Published:
2011
PubMed ID:
21195000