ncRNA basic information
ncRNA ID:
MI0000270/MI0000683
ncRNA Database:
miRBase
ncRNA Name:
miR-181b
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
Notch2
ncRNA Pathway:
Notch2/Hes1 signalling pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
Cancer stem cell (CSC)-like properties were tested by a cell proliferation assay and flow cytometry; miR-181b expression was measured by real-time PCR; and Notch2 and related proteins were detected by Western blotting and immunohistochemistry. A mouse xenograft model was also established.
Drug Response:
sensitive
Cancer basic information
Cancer:
lung non-small cell carcinoma
Tissue/Cell:
cell line (H1650, H1299, A549, and A549/DDP)
Other information
Title:
miR-181b/Notch2 overcome chemoresistance by regulating cancer stem cell-like properties in NSCLC.
Journal:
Stem Cell Res Ther
Published:
2018
PubMed ID:
30470250