ncRNA basic information
ncRNA ID:
MIMAT0002846
ncRNA Database:
miRBase
ncRNA Name:
miR-520c-3p
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
S100A4
ncRNA Pathway:
miR-520c3p/S100A4 pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00997 (APRD00185, DB05331, DB05847)
Drug Name:
Adriamycin
Drug Method:
Quantitative real-time PCR was used to detect HOXA-AS2 expression in the BM samples and ADR cell lines, U/A and T/A cells. Furthermore, the effects of HOXA-AS2 silencing on cell proliferation and apoptosis were assessed in vitro by CCK8 and flow cytometry, and on tumor growth in vivo. Furthermore, bioinformatics online programs predicted and luciferase reporter assay were used to validate the association of HOXA-AS2 and miR-520c-3p in AML.
Drug Response:
resistant
Cancer basic information
Cancer:
acute myeloid leukemia
Tissue/Cell:
cell line (U937 and THP-1)
Other information
Title:
Knockdown of Long Noncoding RNA HOXA-AS2 Suppresses Chemoresistance of Acute Myeloid Leukemia via the miR-520c-3p/S100A4 Axis.
Journal:
Cell Physiol Biochem
Published:
2018
PubMed ID:
30466095