ncRNA basic information
ncRNA ID:
MIMAT0000680
ncRNA Database:
miRBase
ncRNA Name:
miR-106b-5p
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
TDRG1
ncRNA Pathway:
PI3K/Akt/mTOR signaling pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
In this study, using microarray analysis, we found that long non-coding RNA H19 was upregulated while miRNA-106b-5p was downregulated in an established cisplatin-resistant TCam-2 cell line. Moreover, H19 acts as a miRNA-106b-5p sponge and thus impairs the function of miRNA-106b-5p on its target gene, TDRG1. Based on these findings, we propose that H19 promotes the expression of TDRG1 by sequestering miRNA-106b-5p and uses this mechanism to facilitate cell survival in cisplatin-based chemotherapeutic conditions.
Drug Response:
resistant
Cancer basic information
Cancer:
seminoma
Tissue/Cell:
tissue and cell line ( TCam-2)
Other information
Title:
Long non-coding RNA H19 promotes TDRG1 expression and cisplatin resistance by sequestering miRNA-106b-5p in seminoma.
Journal:
Cancer Med
Published:
2018
PubMed ID:
30430771