ncRNA basic information
ncRNA ID:
MI0000073
ncRNA Database:
miRBase
ncRNA Name:
miR-19a
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
CASC2
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by quantitative real-time PCR (qRT-PCR) . Luciferase activity assay was used to verify the target genes of miRNAs.MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs.Flow Cytometric Assay was used to determine if cells were viable, apoptotic, or necrotic. tissue and cell line ( BGC823, SGC7901,BGC823/DDP and SGC7901/DDP)
Drug Response:
sensitive
Cancer basic information
Cancer:
stomach cancer
Tissue/Cell:
tissue and cell line ( GES-1,BGC823, SGC7901,BGC823/DDP and SGC7901/DDP)
Other information
Title:
Down-regulation of CASC2 contributes to cisplatin resistance in gastric cancer by sponging miR-19a.
Journal:
Biomed Pharmacother
Published:
2018
PubMed ID:
30372881