ncRNA basic information
ncRNA ID:
MI0000268
ncRNA Database:
miRBase
ncRNA Name:
miR-34a
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
MAGE-A2,MAGE-A3,MAGE-A6,and MAGE-A12
ncRNA Pathway:
p53 signaling pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by Real-time Quantitative Reverse Transcription-PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. MTS assay was used to test cell proliferation.etc.
Drug Response:
sensitive
Cancer basic information
Cancer:
medulloblastoma
Tissue/Cell:
cell line ( R262, UW228, UW426, R300,D556, D384Med, D425Med,D283,HEK 293T/17)
Other information
Title:
miR-34a confers chemosensitivity through modulation of MAGE-A and p53 in medulloblastoma.
Journal:
Neuro Oncol
Published:
2011
PubMed ID:
21177782