ncRNA basic information
ncRNA ID:
MI0006431
ncRNA Database:
miRBase
ncRNA Name:
miR-1284
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
HMGB1
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The levels of miR-1284 in different tissues and cell lines were detected through using qRT-PCR analysis. Kaplan Meier analysis was utilized to analyze the influence of miR-1284 expression on the overall survival rate of cervical cancer patients. The biological effects of miR-1284 on the progression and chemosensitivity of cervical cancer were tested through conducting functional assays. Mechanism investigations were used to prove the binding relation between miR-1284 and HMGB1. Rescue assays were applied to demonstrate the effects of miR-1284-HMGB1 axis on chemosensitivity of cervical cancer cells.
Drug Response:
sensitive
Cancer basic information
Cancer:
cervical cancer
Tissue/Cell:
tissue and cell line (MS751, HeLa, SiHa, C33 A,ECS)
Other information
Title:
MiR-1284 enhances sensitivity of cervical cancer cells to cisplatin via downregulating HMGB1.
Journal:
Biomed Pharmacother
Published:
2018
PubMed ID:
30257412