ncRNA basic information
ncRNA ID:
MI0000824
ncRNA Database:
miRBase
ncRNA Name:
miR-325
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qPCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
Human microRNA-325 expression was probed by quantitative real-time polymerase chain reaction in both in vitro bladder cancer cell lines and in vivo bladder carcinoma tissues retrieved from patients with cancer. The prognostic potential of human microRNA-325 in predicting postoperative overall survival of patients with bladder cancer was estimated. Endogenous human microRNA-325 was overexpressed by lentiviral transduction in bladder cancer cell lines, T24 and 5637 cells. The tumor regulatory effects of human microRNA-325 upregulation on T24 and 5637 cells were evaluated both in vitro and in vivo.
Drug Response:
sensitive
Cancer basic information
Cancer:
bladder cancer
Tissue/Cell:
cell line (T24, RT4, 5637, HT-1376, J82, UM-UC-3, and TCCSUP)
Other information
Title:
MicroRNA-325 Is a Potential Biomarker and Tumor Regulator in Human Bladder Cancer.
Journal:
Technol Cancer Res Treat
Published:
2018
PubMed ID:
30176759