ncRNA basic information
ncRNA ID:
MI0000439
ncRNA Database:
miRBase
ncRNA Name:
miR-23b
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
Src
ncRNA Pathway:
Src-Akt pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by Quantitative RT PCR (qRT-PCR) and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs.
Drug Response:
sensitive
Cancer basic information
Cancer:
chondrosarcoma
Tissue/Cell:
cell line (SW1353, OUMS-27, CH-2879, CHON-001, C-28/l2)
Other information
Title:
Inhibition of Src by microRNA-23b increases the cisplatin sensitivity of chondrosarcoma cells.
Journal:
Cancer Biomark
Published:
2017
PubMed ID:
28085008