ncRNA basic information
ncRNA ID:
MIMAT0004700
ncRNA Database:
miRBase
ncRNA Name:
miR-331-5p
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
MDR1
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00997 (APRD00185, DB05331, DB05847)
Drug Name:
Doxorubicin
Drug Method:
The expression levels of miRNA were determined by quantitative real-time PCR and those of protein were by Western immunoblotting. Luciferase activity assay was used to verify the target genes of miRNAs. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs.
Drug Response:
resistant
Cancer basic information
Cancer:
leukemia
Tissue/Cell:
cell line ( K562/DOX1, K562/DOX2, K562/DOX3,K562/WT )
Other information
Title:
Down-regulated miR-331-5p and miR-27a are associated with chemotherapy resistance and relapse in leukaemia.
Journal:
J Cell Mol Med
Published:
2011
PubMed ID:
21070600