ncRNA basic information
ncRNA ID:
MI0000811
ncRNA Database:
miRBase
ncRNA Name:
miR-148b
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00997 (APRD00185, DB05331, DB05847)
Drug Name:
Doxorubicin
Drug Method:
The expression patterns of miR-148b, HDAC6, and Ezrin were detected in CHOP-resistant clinical specimens and a DLBCL cell line. miR-148b, HDAC6, and Ezrin in DLBCL cells were manipulated by cell transfection to explore the functional correlation between them. Cell viability was determined using a CCK-8 assay.
Drug Response:
resistant
Cancer basic information
Cancer:
diffuse large B-cell lymphoma
Tissue/Cell:
cell line ( CRL2631)
Other information
Title:
Down-regulated miR-148b increases resistance to CHOP in diffuse large B-cell lymphoma cells by rescuing Ezrin.
Journal:
Biomed Pharmacother
Published:
2018
PubMed ID:
29966970