ncRNA basic information
ncRNA ID:
MI0006405
ncRNA Database:
miRBase
ncRNA Name:
miR-1268a
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
ABCC1
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00853 (APRD00557)
Drug Name:
Temozolomide
Drug Method:
We conducted RNA sequencing (RNA-seq) for GBM cells treated continuously with TMZ 1 or 2 week or not. Bioinformatic analysis was used to predict targets of these altered miRNAs. Subsequently, we studied the potential role of miR-1268a in TMZ-resistance of GBM cells.
Drug Response:
sensitive
Cancer basic information
Cancer:
glioblastoma
Tissue/Cell:
cell line (U87 and LN229)
Other information
Title:
miR-1268a regulates ABCC1 expression to mediate temozolomide resistance in glioblastoma.
Journal:
J Neurooncol
Published:
2018
PubMed ID:
29876787