ncRNA basic information
ncRNA ID:
MI0006336
ncRNA Database:
miRBase
ncRNA Name:
miR-663b
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-qPCR
ncRNA Target Gene:
TP73
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00675 (APRD00123)
Drug Name:
Tamoxifen
Drug Method:
The aim of the present study was to investigate the role of miRNA-663b in TAM resistance in breast cancer.The expression levels of miRNA were determined byReverse transcription-quantitative polymerase chain reaction (RT-qPCR) and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs.
Drug Response:
resistant
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line ( MCF7,MCF7/TAM)
Other information
Title:
MicroRNA-663b mediates TAM resistance in breast cancer by modulating TP73 expression.
Journal:
Mol Med Rep
Published:
2018
PubMed ID:
29845295