ncRNA basic information
ncRNA ID:
MI0000743
ncRNA Database:
miRBase
ncRNA Name:
miR-34c
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
BCL-2 and CCND1
ncRNA Pathway:
BCL-2 and cyclin D1 pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression levels of miRNA were determined by qRT-PCR .The CCK-8 assay was used to monitor the growth of the cells .Flow Cytometric Assay was used to determine if cells were viable, apoptotic, or necrotic. Tumor model was used to test the role of lncRNA NEAT1 and miR-34c .
Drug Response:
sensitive
Cancer basic information
Cancer:
osteosarcoma
Tissue/Cell:
cell line (MG63, 143B, HOS,Saos2,hFOB1.19 )
Other information
Title:
Knockdown of the oncogene lncRNA NEAT1 restores the availability of miR-34c and improves the sensitivity to cisplatin in osteosarcoma.
Journal:
Biosci Rep
Published:
2018
PubMed ID:
29654165