ncRNA basic information
ncRNA ID:
MI0000748
ncRNA Database:
miRBase
ncRNA Name:
miR-130b
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
PTEN
ncRNA Pathway:
Wnt/Beta-catenin pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The role of miR-130b was deteced by qRT-PCR, Western-blotting assay, apoptosis analysis, Luciferase reporter analysis, and Xenografts.
Drug Response:
resistant
Cancer basic information
Cancer:
lung cancer
Tissue/Cell:
cell line ( A549, H446,A549/CR and H446/CR)
Other information
Title:
MicroRNA-130b targets PTEN to induce resistance to cisplatin in lung cancer cells by activating Wnt/Beta-catenin pathway.
Journal:
Cell Biochem Funct
Published:
2018
PubMed ID:
29653464