ncRNA basic information
ncRNA ID:
MI0000064
ncRNA Database:
miRBase
ncRNA Name:
Let-7c
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
In this study, phenotypical behaviors and the radio/chemoresistance were examined subsequent to overexpression of let-7c. In addition, the expression of let-7c in cancer stem cells (CSCs) was evaluated and the effect of let-7c on stemness characteristics was assessed. Also, luciferase activity assays were performed to test whether interleukin (IL)-8 was a putative target of let-7c.
Drug Response:
sensitive
Cancer basic information
Cancer:
oral cancer
Tissue/Cell:
tissue and cell line(SAS, GNM)
Other information
Title:
Let-7c restores radiosensitivity and chemosensitivity and impairs stemness in oral cancer cells through inhibiting interleukin-8.
Journal:
J Oral Pathol Med
Published:
2018
PubMed ID:
29582468