ncRNA basic information
ncRNA ID:
ENSG00000228630
ncRNA Database:
Ensembl
ncRNA Name:
HOTAIR
ncRNA Type:
lncRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
ER signaling
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00675 (APRD00123)
Drug Name:
Tamoxifen
Drug Method:
The role of HOTAIR in breast cancer cells was detected using qPCR, western blotting, Chromosome conformation capture (3C) assay, RNA pulldown assay,RNA immunoprecipitation (RIP), Immunofluoresent staining,Gene expression microarray and data analysis, cell proliferation and clonogenic assay, etc.
Drug Response:
resistant
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line (MCF7 and T47D )
Other information
Title:
LncRNA HOTAIR enhances ER signaling and confers tamoxifen resistance in breast cancer.
Journal:
Oncogene
Published:
2016
PubMed ID:
26364613