ncRNA basic information
ncRNA ID:
MI0000072
ncRNA Database:
miRBase
ncRNA Name:
miR-18a
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
YAP1
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00072 (BTD00098, BIOD00098)
Drug Name:
Trastuzumab
Drug Method:
The role of UCA1and miR-18a in breast cancer cells was detected using qRT-PCR, western blot analysis, CCK-8 assay, Biotin-RNA pull-down assay, apoptosis assay and matrigel invasion analysis,etc.
Drug Response:
sensitive
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line ( SKBR-3)
Other information
Title:
Long non-coding RNA UCA1 desensitizes breast cancer cells to trastuzumab by impeding miR-18a repression of Yes-associated protein 1.
Journal:
Biochem Biophys Res Commun
Published:
2018
PubMed ID:
29408336