ncRNA basic information
ncRNA ID:
MI0000292
ncRNA Database:
miRBase
ncRNA Name:
miR-216a
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-qPCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The role of HOTTIP and miR-216a in small cell lung cancer cells was detected using RT-qPCR, western blot analysis , IHC staining analysis , immunofluorescence analysis , in vitro chemosensitivity assay , apoptosis analysis , luciferase reporter assay and RNA immunoprecipitation (RIP) assay,etc.
Drug Response:
sensitive
Cancer basic information
Cancer:
lung small cell carcinoma
Tissue/Cell:
tissue and cell line (H69, H69AR, H446, H446AR SCLC,NCI-H446,H446AR)
Other information
Title:
Long non-coding RNA HOTTIP promotes BCL-2 expression and induces chemoresistance in small cell lung cancer by sponging miR-216a.
Journal:
Cell Death Dis
Published:
2018
PubMed ID:
29367594