ncRNA basic information
ncRNA ID:
MI0000737
ncRNA Database:
miRBase
ncRNA Name:
miR-200a
ncRNA Type:
miRNA
ncRNA Expression:
down-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
TP53INP1 and YAP1
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00441 (APRD00201)
Drug Name:
Gemcitabine
Drug Method:
Breast cancer cells transfected with mimic or inhibitor for miR-200a was assayed for chemoresistance in vitro. miR-200a expression was assessed by quantitative real-time PCR (qRT-PCR) in breast cancer patients treated with preoperative chemotherapy. Luciferase assays, cell proliferation assay were performed to identify the targets of miR-200a and the mechanism by which it promotes treatment resistance. Survival analysis was used to evaluate the prognosis value of miR-200a.
Drug Response:
sensitive
Cancer basic information
Cancer:
breast cancer
Tissue/Cell:
cell line (MDA-MB-23,MDA-MB-436,MDA-MB-453,BT-549,ZR-75-1,ZR-75-30,T47D,MCF-7,SK-BR-3,MCF-10A)
Other information
Title:
MicroRNA-200a confers chemoresistance by antagonizing TP53INP1 and YAP1 in human breast cancer.
Journal:
BMC Cancer
Published:
2018
PubMed ID:
29329575