ncRNA basic information
ncRNA ID:
MI0006356
ncRNA Database:
miRBase
ncRNA Name:
miR-1294
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
IGF1R
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
The expression of miR-1294 in OC tissues (n=30) and cell lines was measured by qRT-PCR. Cell transfection was carried out to establish miR-1294 overexpression or knockdown. MTT and clone formation assays were performed to examine proliferation in OC cells. Additionally, wound healing and tumor invasion assays were used to investigate cell migration and invasion, respectively. Finally, the expression of epithelial-to-mesenchymal transition (EMT)-associated proteins was measured in OC cells by western blot.
Drug Response:
sensitive
Cancer basic information
Cancer:
ovarian cancer
Tissue/Cell:
cell line ( SKOV3)
Other information
Title:
MiR-1294 confers cisplatin resistance in ovarian Cancer cells by targeting IGF1R.
Journal:
Biomed Pharmacother
Published:
2018
PubMed ID:
30119207