ncRNA basic information
ncRNA ID:
MIMAT0000232
ncRNA Database:
miRBase
ncRNA Name:
miR-199a-3p
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qPCR
ncRNA Target Gene:
CD44
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00997 (APRD00185, DB05331, DB05847)
Drug Name:
Doxorubicin
Drug Method:
The expression levels of miRNA were determined by quantitative polymerase chain reaction . CD44 protein expression in 8 pairs of HCC and benign tissue is presented from the immunoblot and the densitometry values of the immunoblot. Luciferase activity assay was used to verify the target genes of miRNAs. Cell migration was detected by invasion assay.
Drug Response:
sensitive
Cancer basic information
Cancer:
hepatocellular carcinoma
Tissue/Cell:
cell line ( Huh7, HepG2, SNU182, PLC/PRF/5, Hep3B, SNU423, SNU449)
Other information
Title:
miR-199a-3p targets CD44 and reduces proliferation of CD44 positive hepatocellular carcinoma cell lines.
Journal:
Biochem Biophys Res Commun
Published:
2010
PubMed ID:
21055388