ncRNA basic information
ncRNA ID:
MIMAT0000087
ncRNA Database:
miRBase
ncRNA Name:
miR-30a-5p
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
We analyzed the levels of Beclin-1 in etoposide/cisplatin (EP) -resistant and -sensitive cell lines, as well as the relationship between Beclin-1 and patients chemosensitivity. The function of Beclin-1 in chemoresistant SCLC cells in vitro was measured by MTT, WB, colony formation and flow cytometric analysis. Further rescue experiment was performed after co-transfected with siBeclin-1 and miR-30a mimics or inhibitor.
Drug Response:
sensitive
Cancer basic information
Cancer:
lung small cell carcinoma
Tissue/Cell:
tissue and cell line ( H446, Letp,VP16/DDP)
Other information
Title:
Intensified Beclin-1 Mediated by Low Expression of Mir-30a-5p Promotes Chemoresistance in Human Small Cell Lung Cancer.
Journal:
Cell Physiol Biochem
Published:
2017
PubMed ID:
28977798