ncRNA basic information
ncRNA ID:
MI0000735
ncRNA Database:
miRBase
ncRNA Name:
miR-29c
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
DNA mismatch repair pathway
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00853 (APRD00557)
Drug Name:
Temozolomide
Drug Method:
The expression levels of miRNA were determined by Real-time PCR and those of protein were by Western blot analysis. Luciferase activity assay was used to verify the target genes of miRNAs. MTT assay was used to test the drug-resistant phenotype changes in cancer cells via overregulation of miRNAs.
Drug Response:
sensitive
Cancer basic information
Cancer:
glioma
Tissue/Cell:
tissue and cell line (U251, U373, LN229, U118, and LN229)
Other information
Title:
LncRNA-XIST interacts with miR-29c to modulate the chemoresistance of glioma cell to TMZ through DNA mismatch repair pathway.
Journal:
Biosci Rep
Published:
2017
PubMed ID:
28831025