ncRNA basic information
ncRNA ID:
MI0003188
ncRNA Database:
miRBase
ncRNA Name:
miR-503
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
qRT-PCR
ncRNA Target Gene:
bcl-2
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
MiR-503 and bcl-2 mRNA expression levels in hepatocellular carcinoma cells were measured by real-time quantitative (qRT)-PCR; Bcl-protein level was detected by Western blot; miR-503 mimics were transiently transfected to the BEL-7402 cells by liposome transfection; potential target genes of miR-503 were predicted by Bioinformatics software; miR-503 potential targets were validated by dual luciferase activity; and the cell viability was measured by MTT assay.
Drug Response:
sensitive
Cancer basic information
Cancer:
hepatocellular carcinoma
Tissue/Cell:
cell line (HL-7702,BEL-7402)
Other information
Title:
MiR-503 sensitizes human hepatocellular carcinoma cells to cisplatin by targeting bcl-2
Journal:
Zhong Nan Da Xue Xue Bao Yi Xue Ban
Published:
2017
PubMed ID:
28690214