ncRNA basic information
ncRNA ID:
MIMAT0004784
ncRNA Database:
miRBase
ncRNA Name:
miR-455-3p
ncRNA Type:
miRNA
ncRNA Expression:
up-regulated
ncRNA Method:
RT-PCR
ncRNA Target Gene:
NA
ncRNA Pathway:
NA
Evidence (ncRNA-drug):
validated
drug basic information
Drug ID:
DB00515 (APRD00359)
Drug Name:
Cisplatin
Drug Method:
A chemoresistant patient-derived xenograft (PDX) model of human esophageal squamous cell carcinoma (ESCC) was employed to identify microRNAs that contribute to ESCC aggressiveness. The oncogenic effects of microRNA-455-3p (miR-455-3p) on ESCC chemoresistance and tumorigenesis were examined by in vivo and in vitro chemoresistance, tumorsphere formation, side-population, and in vivo limiting dilution assays. The roles of miR-455-3p in activation of the Wnt/Beta-catenin and transforming growth factor-Beta (TGF-Beta)/Smad pathways were determined by luciferase and RNA immunoprecipitation assays.
Drug Response:
resistant
Cancer basic information
Cancer:
esophageal squamous cell carcinoma
Tissue/Cell:
cell line (Eca109, Kyse30,H157,AGS )
Other information
Title:
Antagonizing miR-455-3p inhibits chemoresistance and aggressiveness in esophageal squamous cell carcinoma.
Journal:
Mol Cancer
Published:
2017
PubMed ID:
28633632